Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FGFR inhibitor resistance in cervical cancer: a role for integrin α2 and mTOR signalling.

Frontiers in cell and developmental biology·2026
Same author

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer.

Cell reports·2026
Same author

Corrigendum to "Histamine H1 receptor: a potential therapeutic target for pancreatic ductal adenocarcinoma".

The Journal of pharmacology and experimental therapeutics·2026
Same author

Compartment-specific tumor-infiltrating immune cells and prognosis in breast cancer.

iScience·2026
Same author

Early-Onset Retinopathy in Patients With Variants in SLC6A6 Leading to Impaired Taurine Transport.

JAMA ophthalmology·2025
Same author

Cold receptor TRPM8 as a target for migraine-associated pain and affective comorbidities.

The journal of headache and pain·2025

Related Experiment Video

Updated: Aug 11, 2025

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
08:26

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Published on: February 17, 2012

14.7K

Everybody needs good neighbours: the progressive DCIS microenvironment.

Shayin V Gibson1, Reza M Roozitalab1, Michael D Allen1

  • 1Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.

Trends in Cancer
|February 4, 2023
PubMed
Summary
This summary is machine-generated.

Ductal carcinoma in situ (DCIS), a non-invasive breast cancer, is often overtreated. Understanding the tumor microenvironment is key to better patient stratification and avoiding unnecessary treatments for indolent DCIS cases.

Keywords:
biomarkersbreast cancerductal carcinoma in situinvasiontumour microenvironment

More Related Videos

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.4K
Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
05:21

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

9.8K

Related Experiment Videos

Last Updated: Aug 11, 2025

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
08:26

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Published on: February 17, 2012

14.7K
Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.4K
Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
05:21

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

9.8K

Area of Science:

  • Oncology
  • Cancer Biology
  • Translational Research

Background:

  • Ductal carcinoma in situ (DCIS) is a pre-invasive breast cancer.
  • A significant proportion of DCIS cases (up to 70%) are indolent and may not progress.
  • Current treatment often involves aggressive therapies like surgery, endocrine, and radiotherapy, leading to overtreatment.

Purpose of the Study:

  • To review recent studies on the DCIS microenvironment.
  • To discuss how microenvironmental factors influence DCIS progression.
  • To inform the development of new methods for patient stratification.

Main Methods:

  • Review of clinical and mechanistic studies on the DCIS microenvironment.
  • Analysis of the role of various cell types within the tumor microenvironment.
  • Examination of genetic similarities between DCIS and invasive breast cancer cells.

Main Results:

  • Neoplastic cells in DCIS are genetically similar to invasive breast cancer cells.
  • The tumor microenvironment, not just cellular genetics, appears to drive DCIS progression.
  • Multiple cell types within the microenvironment interact to regulate disease progression.

Conclusions:

  • The tumor microenvironment plays a critical role in DCIS progression.
  • Improved understanding of the DCIS microenvironment is essential for accurate patient stratification.
  • This knowledge can help reduce overtreatment and guide more effective patient care strategies.