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Related Experiment Video

Updated: Aug 11, 2025

Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh

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Published on: September 11, 2021

Autoimmunity and hernia mesh: fact or fiction?

B Jisova¹, J Wolesky², Z Strizova³

¹3Rd Department of Surgery, Motol University Hospital, Prague, Czech Republic. bara.jisova@seznam.cz.

Hernia : the Journal of Hernias and Abdominal Wall Surgery

|February 4, 2023

Summary

This study found little evidence linking polypropylene hernia mesh to autoimmune diseases. While biomaterials can cause foreign body reactions, this does not equate to autoimmunity, and causality remains unproven.

Keywords:

ASIA Autoimmune Autoimmunity Hernia mesh Immune Polypropylene

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Area of Science:

Medical research
Immunology
Surgical materials science

Background:

Increasing patient reports suggest autoimmune or allergic reactions to surgical mesh post-hernia repair.
Hypersensitivity or autoimmunity caused by surgical mesh has not been scientifically proven.
Distinguishing foreign body reactions from true autoimmunity is crucial.

Conclusions:

Limited evidence supports polypropylene mesh causing autoimmunity.
Multiple autoimmunity triggers and genetic predisposition complicate establishing a direct cause-and-effect relationship.
A chronic foreign body reaction to biomaterials is distinct from autoimmunity.