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Circulating microvesicles correlate with radiation proctitis complication after radiotherapy.

Alexandre Ribault1, Mohamed Amine Benadjaoud2, Claire Squiban1

  • 1Institut de Radioprotection Et de Sûreté Nucléaire (IRSN), PSE-SANTE, BP17, 92262, Fontenay-aux-Roses Cedex, France.

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|February 5, 2023
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Summary
This summary is machine-generated.

Circulating microvesicles (MVs) show promise as biomarkers for radiation toxicity. Increased platelet-derived MVs (PMVs) correlate with higher rectal bleeding grades in prostate cancer patients undergoing radiation therapy.

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Area of Science:

  • Oncology
  • Biomarkers
  • Radiation Oncology

Background:

  • Radiation therapy for prostate adenocarcinoma can cause significant toxicity, impacting patient quality of life.
  • Identifying reliable biomarkers for predicting radiation-induced toxicity is crucial for personalized treatment strategies.

Purpose of the Study:

  • To investigate the potential of circulating microvesicles (MVs) as biomarkers for predicting radiation toxicity in prostate cancer patients.
  • To assess the association between different types of MVs and rectal bleeding severity after radiation therapy.

Main Methods:

  • A retrospective study of 208 prostate adenocarcinoma patients treated with radiation therapy.
  • Flow cytometry was used to quantify platelet (P)-, monocyte (M)-, and endothelial (E)-derived MVs.
  • Multivariate logistic regression analyzed the association between MV levels and rectal bleeding toxicity scores.

Main Results:

  • Elevated numbers of platelet-derived MVs (PMVs) were significantly associated with higher grades of rectal bleeding toxicity.
  • Increased PMVs and a higher monocyte-derived MVs (MMVs) to endothelial-derived MVs (EMVs) ratio predicted worse rectal bleeding.
  • PMV and MMV levels correlated with radiation dose exposure to the bladder, rectum, and anterior rectal wall.

Conclusions:

  • Circulating microvesicles, particularly PMVs, show potential as novel biomarkers for identifying patients at high risk of radiation toxicity.
  • MV analysis may aid in the prognosis of radiation therapy complications and inform treatment adjustments.