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Therapeutic DNAzymes: From Structure Design to Clinical Applications

Jiaqi Yan1,2,3, Meixin Ran1,2,3, Xian Shen1,4

  • 1Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325015, China.

Advanced Materials (Deerfield Beach, Fla.)
|February 5, 2023
PubMed
Summary

Therapeutic DNAzymes show promise for gene regulation but face challenges in clinical application due to low in vivo effectiveness. Recent advancements focus on optimizing DNAzyme therapeutics for improved stability, efficacy, and targeted delivery.

Keywords:
clinical advancesmono/synergistic therapystructural designtherapeutic DNAzymes

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