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Related Experiment Videos

Desirable standards for hematology tests: a proposal.

C G Fraser1

  • 1Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.

American Journal of Clinical Pathology
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

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This study proposes using clinical chemistry strategies to set analytic goals for hematology and coagulation tests. These new goals, based on biologic variation, are more stringent and aim for zero bias, improving total laboratory error assessment.

Area of Science:

  • Clinical Pathology
  • Laboratory Medicine
  • Hematology

Background:

  • Limited analytic goals exist for hematology and coagulation tests, often based on subjective clinical opinions.
  • Current consensus strategies for analytic goals in clinical chemistry are well-established.

Purpose of the Study:

  • To propose the adoption of clinical chemistry consensus strategies for setting analytic goals in other clinical pathology disciplines, including hematology and coagulation.
  • To establish more stringent and objective analytic goals based on biologic variation.

Main Methods:

  • Review and adaptation of consensus strategies for analytic goal setting from clinical chemistry.
  • Utilizing average intraindividual biologic variation to define goals for imprecision.
  • Justifying a goal of zero bias for inaccuracy.

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Main Results:

  • Proposed analytic goals for hematology and coagulation tests are more stringent than previously published goals.
  • Recommended goals for imprecision should be considered alongside the goal for inaccuracy (zero bias) to assess total laboratory error.
  • Biologic variation data is crucial for refining these goals.

Conclusions:

  • Consensus strategies from clinical chemistry can be validly applied to hematology and coagulation testing.
  • Analytic goals based on intraindividual biologic variation and zero bias offer a more rigorous framework for total laboratory error.
  • Further research into biologic variation is needed for broader adoption.