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Multidisciplinary Approach to Obesity Management: A Case Report

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Published on: May 30, 2025

A paradigm shift in clinical nutrition.

Diana Cardenas¹, Juan B Ochoa²

¹Nutrition Unit, Institut Gustave Roussy, Villejuif, France.

Clinical Nutrition (Edinburgh, Scotland)

|February 5, 2023

Summary

Disease-related malnutrition (DRM) is not solely caused by a caloric deficit. Current nutrition interventions focusing on food substitution are insufficient. New paradigms are needed for effective DRM treatment and prevention.

Keywords:

Malnutrition Nutrients Paradigm

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Area of Science:

Clinical Nutrition
Pathophysiology
Medical Science

Background:

The prevailing clinical nutrition paradigm links disease-related malnutrition (DRM) to caloric deficits.
Nutrition interventions often focus on artificial nutrition as a food substitution to prevent caloric deficits.

Purpose of the Study:

To challenge the current paradigm of disease-related malnutrition (DRM).
To advocate for a shift from a food substitution model to a mechanistic understanding of DRM.
To highlight the limitations of current nutrition interventions in treating DRM.

Main Methods:

This opinion paper reviews existing evidence and proposes a new perspective on DRM.
It critiques the "food substitution paradigm" in clinical nutrition.
It calls for the development of innovative hypotheses and research into the mechanisms of DRM.

Main Results:

Evidence indicates that DRM is partially resistant to interventions solely aimed at preventing caloric deficits.
Disease-related malnutrition cannot be effectively prevented or treated by simply replacing food intake.
Current nutrition therapy approaches are oversimplified.

Conclusions:

A paradigm shift is necessary in clinical nutrition.
Focus must move beyond caloric replacement to understanding the underlying mechanisms of DRM.
Innovative research is crucial for developing effective treatments and prevention strategies for DRM.