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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Related Experiment Video

Updated: Aug 11, 2025

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
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Prototype-guided multi-scale domain adaptation for Alzheimer's disease detection.

Hongshun Cai1, Qiongmin Zhang1, Ying Long1

  • 1College of Computer Science and Engineering, Chongqing University of Technology, Chongqing, 400054, China.

Computers in Biology and Medicine
|February 5, 2023
PubMed
Summary

This study introduces a novel AI framework, Prototype-Guided Multi-Scale Domain Adaptation (PMDA), for early Alzheimer's disease (AD) diagnosis using brain MRI scans. PMDA effectively addresses domain shift issues, achieving high accuracy in distinguishing AD, Mild Cognitive Impairment (MCI), and Cognitively Normal (CN) individuals.

Failed At:

2026-06-19T13:39:57.868048+00:00

Keywords:
Alzheimer's diseaseDomain adaptationFeature alignmentMulti-scalePrototype MDDStructural MRI

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