Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exposure assessment for occupational epidemiology.

T J Smith1

  • 1Department of Family and Community Medicine, University of Massachusetts Medical School, Worcester 01605.

American Journal of Industrial Medicine
|January 1, 1987
PubMed
Summary

This study proposes a six-step approach for exposure assessment in epidemiology, using pharmacologic models to analyze exposure-effect relationships for environmental toxins. This method improves the evaluation of health effects from variable toxic agent concentrations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols.

Nutrition and cancer·2000
Same author

Predictors of Medicare costs in elderly beneficiaries with breast, colorectal, lung, or prostate cancer.

Health care management science·2000
Same author

Functional TSH receptor in human abdominal preadipocytes and orbital fibroblasts.

American journal of physiology. Cell physiology·2000
Same author

The structure of cucumber mosaic virus and comparison to cowpea chlorotic mottle virus.

Journal of virology·2000
Same author

Implications of different fiber measures for epidemiologic studies of man-made vitreous fibers.

American journal of industrial medicine·2000
Same author

Development of a medical supply set for corpsmen in the field.

Military medicine·2000

Area of Science:

  • Environmental Epidemiology
  • Toxicology
  • Pharmacology

Background:

  • Exposure evaluation in epidemiology requires understanding the exposure-effect relationship, which is influenced by pharmacological processes.
  • Environmental toxicant concentrations fluctuate, leading to variable tissue concentrations and subsequent health effects over time.
  • Existing methods for exposure assessment may not adequately capture the dynamic nature of exposure and its relationship to health outcomes.

Purpose of the Study:

  • To propose a general, six-step approach for developing exposure assessments in epidemiologic studies.
  • To integrate pharmacologic models into exposure assessment to guide measurement and data analysis.
  • To introduce 'effect indices' for quantifying temporal exposure-pharmacologic model interrelationships.

Main Methods:

Related Experiment Videos

  • Development of a six-step framework for exposure assessment.
  • Application of pharmacologic models to guide the selection of exposure measurement parameters.
  • Utilization of effect indices to quantify the temporal dynamics between exposure profiles and pharmacologic models.

Main Results:

  • The proposed six-step approach provides a structured method for exposure assessment in epidemiology.
  • Pharmacologic models effectively guide the choice of exposure metrics and data analysis strategies.
  • Effect indices offer a superior method for quantifying exposure-effect relationships compared to traditional dose indices or simple dose-outcome models.

Conclusions:

  • A pharmacologically-guided, six-step exposure assessment approach enhances epidemiologic studies.
  • This framework improves the analysis of health effects from temporally variable environmental exposures.
  • Effect indices represent a novel and advantageous tool for characterizing exposure-response dynamics in toxicology and epidemiology.