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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
[Clinical discussion on methimazole in the treatment of hyperthyroidism]
1Chinese Academy of Medical Sciences, Peking Union Medical College, Department of Endocrinology, Peking Union Medical College Hospital, NHC Key Laboratory of Endocrinology, Beijing, 100730, China.
Abstract:
Methimazole is the most commonly used medication for hyperthyroidism with good effects and little adverse reactions. However, improper selection of initial dose will affect the efficacy, such as excessive dose is proven to various adverse reactions; insufficient dose can hardly achieve desired efficacy. Based on the literature and personal clinical experience, the author discusses the following clinical issues related to methimazole in the treatment of hyperthyroidism, including the selection of initial dose, dose adjustment and withdrawal of methimazole, drug therapy for patients with liver function injury, and management strategies for methimazole-related adverse reactions.
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