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Roles of Microglia in AD Pathology

Gao Rong1, Wu Hongrong2, Li Qingqi3

  • 1Department of Physiology, Hengyang Medical School, University of South China, Hengyang, P.R. China.

Current Alzheimer Research
|February 6, 2023
PubMed

Insights

Microglia play key roles in Alzheimer's disease (AD) by influencing amyloid-beta (Aβ) and tau pathologies. Targeting microglial functions offers potential therapeutic strategies for AD.

Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles.
  • Microglia, the brain's immune cells, are implicated in AD pathogenesis.
  • Their specific roles in Aβ and tau pathology require detailed understanding.

Conclusions:

  • Microglia are central players in Alzheimer's disease pathology.
  • Targeting microglial pathways presents a promising therapeutic avenue for AD.
  • Further research into microglial functions can lead to effective AD treatments.
Keywords:
Alzheimer’s diseaseamyloid βmicroglianeurofibrillary tanglesphagocytestau

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