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Right upper lobe pulmonary sequestration masquerading clinically and radiologically as malignancy: a case report.
Ankit Gupta1, Gavin Chetty2, David Hopkinson2
1School of Medicine, Worsley Building, University of Leeds, Woodhouse, Leeds, LS2 9JT, UK.
Journal of Surgical Case Reports
|February 6, 2023
Summary
This case highlights an unusual presentation of bronchopulmonary sequestration, a rare lung condition. The patient experienced unexplained weight loss, and imaging initially suggested malignancy, but surgery revealed sequestration.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Radiology
Background:
- Bronchopulmonary sequestration (BPS) is a congenital lung malformation characterized by non-functional lung tissue with anomalous systemic arterial supply and absent communication with the tracheobronchial tree.
- BPS typically occurs in the lower lung lobes and can present with diverse symptoms, including recurrent infections or respiratory distress.
Observation:
- A 30-year-old female presented with unexplained weight loss as the sole clinical symptom.
- Computed tomography (CT) revealed a right upper lobe mass, initially suspected to be mediastinal lymphoma or thymic malignancy.
- Video-assisted thoracoscopic surgery (VATS) was performed for diagnostic and therapeutic purposes.
Findings:
- Surgical exploration excluded malignancy, identifying bronchopulmonary sequestration as the underlying pathology.
- Histopathological examination confirmed the diagnosis of bronchopulmonary sequestration.
- The patient recovered well following surgical resection.
Implications:
- This case underscores the importance of considering rare diagnoses like BPS even with atypical presentations, such as isolated weight loss and upper lobe location.
- The radiological mimicry of malignancy highlights challenges in preoperative diagnosis and the crucial role of surgical intervention.
- This atypical presentation expands the clinical spectrum of bronchopulmonary sequestration, emphasizing the need for comprehensive diagnostic evaluation.

