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Updated: Aug 11, 2025

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Classic psychedelics do not affect T cell and monocyte immune responses.

Deborah Rudin1,2, Alexander Areesanan3, Matthias E Liechti1,2

  • 1Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Frontiers in Psychiatry
|February 6, 2023
PubMed
Summary

Classic psychedelics like LSD and psilocin do not directly impact human T cell proliferation or cytokine release. This research supports their safe use in psychotherapy, even for patients with compromised immune systems.

Keywords:
DMTLSDT cellmescalinemonocytepsilocinpsychedelic

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Area of Science:

  • Immunology
  • Psychopharmacology
  • Cell Biology

Background:

  • Classic psychedelics show therapeutic potential for psychiatric disorders.
  • Psychedelics may modulate immune functions, but direct effects on human immune cells are under-explored.
  • T cells are crucial for immune function, and their inhibition raises infection risk.

Purpose of the Study:

  • To investigate the direct immune-modulatory effects of classic psychedelics on human immune cells.
  • To assess the impact of LSD, psilocin, DMT, and mescaline on T cell proliferation and cytokine release.
  • To evaluate the effect of these psychedelics on NF-κB induction in monocytes.

Main Methods:

  • Primary human T lymphocytes and monocytes were used for in vitro studies.
  • Proliferation and stimulated cytokine release of T cells were measured.
  • NF-κB induction in monocytes was assessed following stimulation.

Main Results:

  • No significant direct immune-modulatory effects were observed for LSD, psilocin, DMT, or mescaline.
  • The tested psychedelics did not stimulate T cell proliferation or cytokine secretion.
  • NF-κB induction in monocytes was not directly stimulated by these compounds.

Conclusions:

  • Classic psychedelics (LSD, psilocin, DMT, mescaline) do not directly affect human T lymphocyte or monocyte functions in vitro.
  • These findings suggest that classic psychedelics can be safely used in assisted psychotherapy.
  • The study supports the use of psychedelics in patients with life-threatening conditions where immune function is critical.