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Updated: Aug 11, 2025
Isolation and Identification of Extravascular Immune Cells of the Heart
Published on: August 23, 2018
The role of major immune cells in myocardial infarction
Qiang Feng1,2, Qirong Li2, Hengzong Zhou2
1Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China.
Insights
Myocardial infarction (MI) involves complex immune responses. Engineered cardiac patches offer a promising therapeutic approach for treating this cardiovascular disease (CVD).
Area of Science:
- Cardiovascular Science
- Immunology
- Regenerative Medicine
Background:
- Myocardial infarction (MI), a leading cause of cardiovascular disease (CVD) mortality, triggers significant immune system activation.
- Immune cells are crucial throughout MI progression, clearing necrotic tissue and promoting repair.
- Adverse cardiac remodeling and heart failure often follow MI, necessitating effective treatments.
Purpose of the Study:
- To review the role of immune cells in myocardial infarction (MI) development.
- To summarize common animal models used for studying MI.
- To discuss the potential of engineered cardiac patches for MI repair.
Main Methods:
- Literature review of immune cell involvement in MI.
- Analysis of established animal models for MI research.
- Examination of recent advancements in cardiac patch technology.
Main Results:
- Immune cells orchestrate both the inflammatory and reparative phases post-MI.
- Animal models provide essential platforms for understanding MI pathophysiology.
- Engineered cardiac patches show potential for functional cardiac repair.
Conclusions:
- Understanding immune cell dynamics is key to managing MI.
- Appropriate animal models are vital for preclinical MI research.
- Cardiac patch technology represents a promising therapeutic avenue for MI treatment.
Abstract:
Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, often leading to adverse cardiac remodeling and heart failure, which is a serious threat to human life and health. The immune system makes an important contribution to the maintenance of normal cardiac function. In the disease process of MI, necrotic cardiomyocytes release signals that activate nonspecific immunity and trigger the action of specific immunity. Complex immune cells play an important role in all stages of MI progression by removing necrotic cardiomyocytes and tissue and promoting the healing of damaged tissue cells. With the development of biomaterials, cardiac patches have become an emerging method of repairing MI, and the development of engineered cardiac patches through the construction of multiple animal models of MI can help treat MI. This review introduces immune cells involved in the development of MI, summarizes the commonly used animal models of MI and the newly developed cardiac patch, so as to provide scientific reference for the accurate diagnosis and effective treatment of MI.
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