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Related Experiment Videos

Indicators of perinatal asphyxia.

D I Hollander1, L Wright, D A Nagey

  • 1Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore.

American Journal of Obstetrics and Gynecology
|October 1, 1987
PubMed
Summary
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Creatinine phosphokinase (CPK) and its isoenzymes (MB and BB) can indicate tissue injury. Elevated CPK levels in newborns may serve as objective markers for perinatal asphyxia, correlating with fetal distress and acid-base abnormalities.

Area of Science:

  • Biochemistry
  • Neonatal Medicine
  • Perinatal Research

Background:

  • Creatinine phosphokinase (CPK) and its isoenzymes (myocardial-specific MB and brain-specific BB) are established markers of tissue injury.
  • Assessing perinatal asphyxia often relies on clinical observation, which may not always capture the full extent of tissue damage.
  • Objective biochemical markers are needed for a more accurate diagnosis of perinatal asphyxia.

Purpose of the Study:

  • To evaluate the utility of serum creatinine phosphokinase (CPK) and its isoenzymes (MB and BB) as objective indicators of perinatal asphyxia.
  • To correlate CPK levels with fetal distress and acid-base status in newborns.

Main Methods:

  • Prospective study of 49 neonates with gestational ages between 36 and 42 weeks.
  • Analysis of umbilical venous blood for pH and base excess.

Related Experiment Videos

  • Measurement of umbilical venous cord CPK isoenzymes (MB and BB).

    • Main Results:

    • Patients diagnosed with fetal distress based on fetal heart rate tracings showed significantly lower umbilical venous pH and base excess.
    • Elevated levels of umbilical venous cord MB and BB isoenzymes were observed in the fetal distress group.
    • Abnormal fetal heart rate patterns correlated well with acid-base abnormalities and elevated CPK levels.

    Conclusions:

    • Elevated creatinine phosphokinase (CPK) isoenzymes (MB and BB) in umbilical cord blood are associated with fetal distress and acid-base disturbances.
    • CPK and its isoenzymes show promise as objective indicators of tissue injury in perinatal asphyxia.
    • These biochemical markers may offer a more sensitive assessment of tissue damage compared to clinical evaluation alone.