Related Experiment Video

Updated: Aug 11, 2025

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

1.3K

Predictive Value of Hyperuricemia in Cardiac Patients with Post-Contrast Acute Kidney Injury (PC-AKI) and Different

Angshu Cai1, Tian Zhou2

  • 1Queen Mary School, Nanchang University, Nanchang 330031, China.

Iranian Journal of Public Health
|February 6, 2023
PubMed

Insights

Hyperuricemia increases the risk of post-contrast acute kidney injury (PC-AKI). This association is stronger in patients with normal kidney function, suggesting urate-lowering therapy could prevent PC-AKI.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • The relationship between uric acid levels and post-contrast acute kidney injury (PC-AKI) is debated.
  • It is unclear if hyperuricemia predicts PC-AKI in patients with varying baseline kidney function.

Purpose of the Study:

  • To determine if hyperuricemia is an independent risk factor for PC-AKI.
  • To investigate the association between hyperuricemia and baseline renal function.

Main Methods:

  • A meta-analysis of studies published in English and Chinese databases (PubMed, Embase, Cochrane Library, WAN FANG) up to January 2022.
  • Included 15 studies with a total of 11,892 patients.

Main Results:

  • Hyperuricemia was linked to a significantly higher incidence of PC-AKI (20.62% vs. 13.05%).
  • Hyperuricemia increased the risk of PC-AKI (OR: 2.48), mortality (OR: 2.33), and renal replacement therapy (OR: 8.69).
  • The relative risk of PC-AKI in hyperuricemia patients was lower in those with pre-existing renal dysfunction.

Conclusions:

  • Hyperuricemia is significantly associated with PC-AKI incidence.
  • The impact of serum uric acid on PC-AKI is more pronounced in patients with normal renal function.
  • Findings support individualized PC-AKI prevention strategies using urate-lowering therapy.
Abstract

Keywords:
Creatinine serumHyperuricemiaPost-contrast acute kidney injury

More Related Videos

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.2K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.5K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
50
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
131
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
52
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
46
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
54
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
39