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Cardiorespiratory Insufficiency and Performance Fatigability in Women with Systemic Lupus Erythematosus
Liana C Wooten1,2,3, Sarfaraz Hasni4, Jamal A Mikdashi5
1Tufts University, Department of Public Health and Community Medicine, Division of Doctorate of Physical Therapy (DPT), Phoenix, Arizona.
Cardiopulmonary Physical Therapy Journal
|February 6, 2023
Summary
Systemic lupus erythematosus (SLE) patients exhibit significant performance fatigability, linked to cardiorespiratory impairment. This fatigue occurs even at low exercise intensities, impacting physical function.
Area of Science:
- Cardiopulmonary Exercise Physiology
- Rheumatology
- Exercise Science
Background:
- Systemic lupus erythematosus (SLE) is associated with debilitating fatigue.
- Cardiorespiratory impairments are implicated in SLE-related fatigue.
- Objective quantification of performance fatigability in SLE is underexplored.
Purpose of the Study:
- To characterize performance fatigability in women with SLE.
- To investigate cardiorespiratory impairment as a determinant of fatigue in SLE.
- To utilize anaerobic threshold measures for fatigue assessment.
Main Methods:
- Case-control study involving 26 women with SLE and 18 healthy controls.
- Participants completed a maximal treadmill cardiopulmonary exercise test.
- Measures included anaerobic threshold oxygen consumption (AT-VO2) and Fatigue Severity Score (FSS).
Main Results:
- Women with SLE demonstrated significantly lower AT-VO2 compared to controls.
- Higher BMI and lower resting heart rate were observed in the SLE group.
- Fatigue Severity Score was inversely correlated with AT-VO2 and positively with Functional Aerobic Impairment.
Conclusions:
- Patients with SLE exhibit severe performance fatigability.
- Cardiorespiratory insufficiency is a key factor in SLE-related performance fatigability.
- Fatigue manifests at low exercise intensities, negatively affecting physical function.
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