Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.9K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.9K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

15
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
15
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.1K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

27
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
27
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

15
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
15
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

21
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
21

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of a prototype electric silicone oil injector and aspirator in vitreoretinal surgery.

Frontiers in medicine·2026
Same author

Text-guided few-shot liver and tumor segmentation.

Frontiers in digital health·2026
Same author

Genomics of dendritic cell pyruvate metabolism reveals stage-associated circulating immune signatures in diabetic retinopathy.

Experimental eye research·2026
Same author

Gallic acid exerts therapeutic effects on sciatica by reducing inflammatory responses through the regulation of NOX4-mediated oxidative stress.

Frontiers in immunology·2026
Same author

Pathogen-oriented targeted next-generation sequencing as an adjunctive tool for detection of pathogens in endophthalmitis: a retrospective clinical evaluation.

Frontiers in medicine·2026
Same author

<i>Solms-laubachia garzeensis</i> (Brassicaceae), a new species from the Hengduan Mountains of Sichuan Province, China.

PhytoKeys·2026

Related Experiment Video

Updated: Aug 11, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

712

Lysosomal dysfunction in diabetic cardiomyopathy.

Satoru Kobayashi1, Younghee Hahn1, Brett Silverstein1

  • 1Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, New York, NY, United States.

Frontiers in Aging
|February 6, 2023
PubMed
Summary
This summary is machine-generated.

Diabetic cardiomyopathy, a heart condition in diabetics, involves lysosomal dysfunction. This review explores lysosomal injury and its role in diabetic heart disease, impacting heart failure risk.

Keywords:
autophagycardiomyopathycardiovasculardiabeteslysosomal membrane damagelysosome

More Related Videos

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

245
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

10.2K

Related Experiment Videos

Last Updated: Aug 11, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

712
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

245
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

10.2K

Area of Science:

  • Cardiovascular Science
  • Cell Biology
  • Metabolic Disorders

Background:

  • Diabetes mellitus significantly increases cardiovascular complication risk.
  • Diabetic cardiomyopathy, distinct from vascular issues, elevates heart failure and mortality in diabetic patients.
  • Lysosomes, traditionally viewed as waste disposal units, are now recognized as crucial signaling hubs regulating cellular metabolism.

Purpose of the Study:

  • To review recent findings on lysosomal injury in the context of diabetic cardiomyopathy.
  • To elucidate the connection between lysosomal dysfunction and the pathophysiology of the diabetic heart.

Main Methods:

  • Literature review of recent scientific advances.
  • Synthesis of current understanding regarding lysosomal roles and dysfunction in diabetic hearts.

Main Results:

  • Lysosomes are critical signaling centers involved in cellular metabolic adaptation.
  • Lysosomal dysfunction is increasingly implicated in the development of diabetic cardiomyopathy.
  • The precise mechanisms linking lysosomal injury to diabetic heart disease are under active investigation.

Conclusions:

  • Lysosomal dysfunction represents a key pathological event in diabetic cardiomyopathy.
  • Further research into lysosomal injury mechanisms is crucial for understanding and treating diabetic heart complications.