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A 3D Organotypic Melanoma Spheroid Skin Model
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Oral Malignant Melanoma.

Shruti Venugopalan1, Rajesh Makadia2, Monil Parsana1

  • 1P.D.U. Medical College and Hospital, Vasna Road, Vadodara-380006, Rajkot, Gujarat India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|February 6, 2023
PubMed
Summary

This case study highlights a successful treatment of oral malignant melanoma in a 55-year-old female. Early detection and surgical intervention followed by chemoradiotherapy led to excellent outcomes with no complications at 15 months.

Keywords:
Carcinoma gingivaCarcinoma palateHyperpigmented oral lesionsMucosal melanosisOral malignant melanoma

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Area of Science:

  • Oncology
  • Oral Medicine
  • Surgical Pathology

Background:

  • Oral malignant melanoma is a rare but aggressive cancer.
  • Early diagnosis and prompt treatment are crucial for patient survival.
  • Gingival swelling and bleeding can be presenting symptoms.

Purpose of the Study:

  • To present a case of oral malignant melanoma.
  • To illustrate the diagnostic and management pathway.
  • To emphasize the importance of early detection and multimodal treatment.

Main Methods:

  • Histopathological diagnosis of oral malignant melanoma via punch biopsy.
  • Staging with CT of PNS and Neck, and Abdominal/Pelvic Ultrasound.
  • Surgical management: left lower partial maxillectomy and left radical neck dissection.
  • Adjuvant chemoradiotherapy.

Main Results:

  • Successful surgical resection with no intra-operative or post-operative complications.
  • Patient tolerated adjuvant chemoradiotherapy well.
  • No complications observed at 15-month follow-up.

Conclusions:

  • Oral malignant melanoma, though rare, is treatable with a combination of surgery and chemoradiotherapy.
  • Early detection significantly improves prognosis and treatment outcomes.
  • Multidisciplinary management is key for effective patient care.