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The Role of Oxidants and Antioxidants in Chronic Tonsillitis

R Chethana1, P P Devan2, K Sushmitha3

  • 1Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|February 6, 2023
PubMed

Insights

Children with chronic tonsillitis experience significant oxidative stress. Tonsillectomy reduced this stress, indicating the surgery

Area of Science:

  • Pediatric Medicine
  • Biochemistry
  • Immunology

Background:

  • Chronic tonsillitis is a common pediatric condition.
  • Oxidative stress, an imbalance between oxidants and antioxidants, is implicated in various inflammatory diseases.

Purpose of the Study:

  • To investigate the role of oxidants and antioxidants in pediatric chronic tonsillitis.
  • To evaluate the impact of tonsillectomy on oxidative stress markers in children.

Main Methods:

  • A study involving 60 children (3-14 years) with chronic tonsillitis (test group) and 30 healthy controls.
  • Measurement of Malondialdehyde (MDA) as an oxidant marker and Total Antioxidant Capacity (TAC) & Superoxide Dismutase (SOD) as antioxidant markers in blood.
  • Preoperative and 1-month postoperative measurements in the test group; single measurement in the control group.

Main Results:

  • Significantly elevated MDA levels (oxidants) and reduced TAC and SOD levels (antioxidants) in children with chronic tonsillitis compared to controls.
  • MDA levels decreased, while TAC and SOD levels increased post-tonsillectomy, though they did not fully normalize within one month.

Conclusions:

  • Oxidants and antioxidants play a significant role in the pathophysiology of chronic tonsillitis in children.
  • Tonsillectomy appears to alleviate oxidative stress in children with chronic tonsillitis, suggesting a beneficial effect of the surgery.

Keywords:
MalondialdehydeSuperoxide dismutaseTonsillectomyTotal antioxidant capacity

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