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Primary Laryngeal Granulocytic Sarcoma: A Case Report.

Ugurtan Ergun1, Abdulhalim Aysel1, Fatih Yılmaz1

  • 1Department of Otorhinolaryngology and Head and Neck Surgery, Health Sciences University Bozyaka Training and Research Hospital, Bahar, Saim Çıkrıkçı Cd. No:59, 35170 Karabağlar, İzmir, Turkey.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|February 6, 2023
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Summary

Granulocytic sarcoma, a rare extramedullary tumor, can involve the larynx. This case highlights granulocytic sarcoma associated with acute myeloid leukemia presenting as separate neck and mediastinal masses.

Keywords:
Acute myeloid leukemiaChronic myeloid leukemiaGranulocytic sarcomaLarynx

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Area of Science:

  • Oncology
  • Hematology
  • Pathology

Background:

  • Granulocytic sarcoma (GS) is a tumor composed of myeloid precursors, typically associated with myeloid leukemias.
  • Extramedullary involvement is characteristic of GS, but laryngeal presentation is exceptionally rare.
  • The case involves acute myeloid leukemia with unusual extramedullary disease manifestation.

Purpose of the Study:

  • To report a rare case of laryngeal granulocytic sarcoma.
  • To describe the clinical presentation of GS with concurrent acute myeloid leukemia.
  • To highlight the diagnostic and management challenges of rare extramedullary presentations.

Main Methods:

  • Case report detailing clinical findings, diagnostic procedures, and treatment.
  • Review of relevant literature on granulocytic sarcoma and laryngeal involvement.
  • Pathological examination of tissue samples for definitive diagnosis.

Main Results:

  • A patient presented with acute myeloid leukemia and granulocytic sarcoma.
  • The granulocytic sarcoma manifested as two distinct masses in the neck and mediastinum, with laryngeal involvement.
  • Diagnosis was confirmed through histopathological analysis.

Conclusions:

  • Granulocytic sarcoma can present with laryngeal involvement, even as separate neck and mediastinal masses.
  • This case underscores the importance of considering rare extramedullary manifestations in myeloid leukemia.
  • Prompt diagnosis and multidisciplinary management are crucial for optimizing patient outcomes.