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Acute megakaryocytic leukemia with myeloid/monocytic differentiation
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
The American Journal of Surgical Pathology
|November 1, 1987
Abstract:
Acute megakaryocytic leukemia is a rare form of acute nonlymphocytic leukemia that occurs with increased frequency in patients with Down's syndrome. Herein, we report a child with Down's syndrome who presented with a large retroperitoneal mass due to acute megakaryocytic leukemia. Immunohistochemical stains of the tumor cells also demonstrated evidence of myeloid/monocytic differentiation, with positivity for alpha-1-antitrypsin, alpha-1-chymotrypsin, and lysozyme. The significance of this phenotypic heterogeneity is unclear and awaits further studies of similar cases.