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Updated: Aug 11, 2025

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
Published on: February 24, 2016
Use of Collagen Sheets as Graft Material for Myringoplasty
Parth Makwana1, Sohil I Vadiya1, Sridhar Khetani1
1Department of ENT, Dr MK Shah Medical College and Research Centre, Visat, Gandhinagar Highway, Chandkheda, Ahmedabad, Gujarat 382424 India.
Abstract:
The purpose of the study is to investigate how Collagen sheet used as graft material in Myringoplasty improves hearing and tympanic membrane tissue repair in patients with tympanic membrane perforation (TMP) in an office based procedure. Total 50 cases included in the study where Collagen sheet used as graft material for myringoplasty in small to moderate size tympanic membrane perforations(TMP) and procedure performed in an office based set up with the help of a High definition endoscope and camera. Cases followed up regularly and results observed in terms of graft uptake and complete closure of TMP and hearing improvement. Out of 50, complete closure of TMP observed in 39 cases and an average hearing gain of 9.9 db noted in these cases. Success rate of 78% achieved and failed cases were subjected to traditional post auricular method of myringoplasty under microscopic guidance. Myringoplasty with the help of collagen sheet material in an office based set up is an easy, minimally invasive and effective technique and it avoids need for major invasive intervention in a significant number of patients.

