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COVID-19 in patients with pre-existing chronic liver disease - predictors of outcomes

Dinesh Walia1, Anoop Saraya1, Deepak Gunjan2

  • 1Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, New Delhi, India.

World Journal of Virology
|February 6, 2023
PubMed

Insights

Patients with chronic liver disease (CLD), especially cirrhosis, face poor outcomes with COVID-19. Identifying predictors of adverse events is crucial for managing these high-risk patients.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) presents significant risks for patients with chronic liver disease (CLD).
  • Cirrhosis exacerbates COVID-19 severity, leading to increased risks of hepatic decompensation, acute-on-chronic liver failure, and mortality.

Purpose of the Study:

  • To identify predictors of adverse clinical outcomes, including mortality, in patients with CLD and COVID-19.
  • To aid in risk stratification and inform clinical management strategies for this vulnerable population.

Main Methods:

  • This review synthesizes data from existing studies evaluating factors associated with COVID-19 outcomes in CLD patients.
  • Key factors analyzed include liver disease severity, comorbidities, age, and COVID-19 severity.

Main Results:

  • Outcomes for patients with cirrhosis and COVID-19 are generally unfavorable.
  • Data indicates a higher risk of severe complications and mortality in this group.

Conclusions:

  • Predictors of adverse outcomes in CLD patients with COVID-19 require identification for effective prognostication.
  • Informed management strategies are essential for improving clinical outcomes in patients with chronic liver disease and COVID-19.

Keywords:
CirrhosisOutcomesPredictorsSevere acute respiratory syndrome coronavirus 2

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