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Therapeutic Vaccination for HPV-Mediated Cancers

Flora Yan1, Lindsay G Cowell2, Anna Tomkies3

  • 1Department of Otolaryngology-Head and Neck Surgery, Temple University, Philadelphia, PA USA.

Current Otorhinolaryngology Reports
|February 6, 2023
PubMed
Abstract

Insights

Therapeutic vaccines show promise for human papillomavirus (HPV)-mediated cancers, particularly when combined with other treatments. Ongoing research aims to improve efficacy for HPV-related malignancies.

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • Human papillomavirus (HPV) is a major cause of various cancers.
  • Therapeutic vaccines aim to eliminate existing tumor cells by stimulating an immune response.
  • Current treatment strategies for HPV-mediated malignancies require novel approaches.

Purpose of the Study:

  • To review the fundamental concepts of therapeutic vaccines for HPV-mediated cancers.
  • To discuss the current efficacy and delivery platforms of therapeutic HPV vaccines.
  • To explore future directions and potential combinations for HPV vaccine therapy.

Main Methods:

  • This is a narrative review.
  • Literature search on therapeutic HPV vaccines and their clinical applications.
  • Analysis of randomized controlled trials and ongoing studies.

Main Results:

  • Therapeutic HPV vaccines utilize diverse antigen delivery platforms (DNA, RNA, peptides, proteins, vectors, APCs).
  • Efficacy is demonstrated in cervical intraepithelial neoplasia.
  • Limited efficacy in established HPV-mediated malignancies, but promising results in ongoing trials, especially in combination therapies.

Conclusions:

  • Therapeutic HPV vaccines have a strong biological basis for treating HPV-mediated malignancies.
  • Combination therapies, including immune checkpoint inhibitors, are anticipated to enhance vaccine effectiveness.
  • Further research and clinical trials are crucial for optimizing therapeutic HPV vaccine strategies.
Keywords:
CancerHuman papillomavirusTherapeutic vaccine

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