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Updated: Aug 11, 2025
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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
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A Patient With Recurrent Immune Stromal Keratitis and Adherence Challenges
Amanda Glickman1,2, Amanda Hunter1,2, Paul B Greenberg1,3
1Eye Clinic, Providence Veterans Affairs Medical Center, Rhode Island.
Summary
Immune stromal keratitis (ISK), a form of herpes simplex keratitis (HSK), can cause chronic eye inflammation. Early diagnosis and oral antiviral therapy are crucial for managing this potentially blinding condition.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Herpes simplex keratitis (HSK) is a prevalent cause of corneal blindness.
- Immune stromal keratitis (ISK), a subtype of HSK, involves corneal infiltration and neovascularization.
- ISK can lead to chronic, low-grade keratitis for extended periods.
Purpose of the Study:
- To highlight the clinical presentation and diagnostic considerations for immune stromal keratitis (ISK).
- To emphasize the importance of early recognition and treatment of ISK.
Main Methods:
- A case presentation of a 52-year-old male with unilateral eye symptoms.
- Clinical evaluation including assessment of corneal sensitivity and presentation.
- Consultation with a corneal specialist for presumptive diagnosis.
Main Results:
- The patient presented with unilateral watery, itchy, and mildly blurred vision.
- A presumptive diagnosis of ISK was made based on unilateral corneal findings and reduced sensitivity.
Conclusions:
- Immune stromal keratitis (ISK) typically presents unilaterally with reduced corneal sensitivity and nonspecific symptoms.
- ISK should be a primary consideration in patients with unilateral corneal edema, opacification, or neovascularization.
- Initiation of oral antiviral therapy is recommended for suspected ISK cases.
