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Related Concept Videos

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
171
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

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Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
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Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

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Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
649
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

244
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
244
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

127
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
127
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

498
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
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Related Experiment Video

Updated: Aug 11, 2025

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
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Ulceration by Nocardia Otitidiscaviarum: A case study.

Ashish William1, Ravinder Kaur2, Deepti Rawat3

  • 128856Senior Resident, Department of Microbiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, India.

Tropical Doctor
|February 6, 2023
PubMed
Summary

Nocardiosis, an infectious disease, can manifest in skin, lung, or disseminated forms. This case highlights successful treatment of a post-COVID-19 patient with cutaneous nocardiosis using cotrimoxazole and linezolid.

Keywords:
Nocardia otitidiscaviarumNocardiosiscorticosteroidcutaneous nocardiosis

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Dermatology

Background:

  • Nocardiosis is a rare bacterial infection caused by Nocardia species.
  • It can present in cutaneous, pulmonary, or disseminated forms.
  • Post-COVID-19 patients may be susceptible to opportunistic infections.

Observation:

  • A case of cutaneous nocardiosis is presented in a patient recovering from COVID-19.
  • The patient presented with a cutaneous ulceration.
  • The causative agent was identified as Nocardia otitidiscaviarum.

Findings:

  • The patient was successfully managed with a combination therapy of cotrimoxazole and linezolid.
  • Early diagnosis and prompt treatment were critical for a positive outcome.
  • This approach prevented the dissemination of the Nocardia infection.

Implications:

  • This case underscores the importance of considering Nocardia infections in immunocompromised individuals, including post-COVID-19 patients.
  • Effective treatment strategies involving cotrimoxazole and linezolid can lead to favorable outcomes.
  • Further research into the link between COVID-19 and Nocardiosis susceptibility is warranted.