Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging
Miki Kohei1, Naoki Takizawa2, Ryosuke Tsutsumi1
1Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. kumagai-ny@pha.keio.ac.jp.
Abstract:
The C4N4 fluorophore is an intense fluorescence emitter featuring a 2,5-diaminopyrimidine core comprising four carbon and four nitrogen atoms. A series of C4N4 derivatives was photochemically dimerized at the 5-amino group, furnishing overcrowded ortho-tetraaryl-substituted diaryl azo compounds with a characteristic skewed structure revealed by X-ray crystallography. The photoquenched azo-C4N4s are useful for fluorescently visualizing cells under hypoxic conditions.
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