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Updated: Aug 11, 2025

Healthy Brain-pituitary Slices for Electrophysiological Investigations of Pituitary Cells in Teleost Fish
Published on: August 16, 2018
[The caudal neurosecretory system, the other "neurohypophysial" system in fish]
Hervé Tostivint1, Fabrice Girardot1, Caroline Parmentier2
1Muséum National d'Histoire Naturelle, CNRS UMR 7221, Physiologie moléculaire et adaptation, 75005 Paris, France.
Abstract:
The caudal neurosecretory system (CNSS) is a neuroendocrine complex whose existence is specific to fishes. Structurally, it has many similarities with the hypothalamic-neurohypophyseal complex of other vertebrates. However, it differs regarding its position at the caudal end of the spinal cord and the nature of the hormones it secretes, the most important being urotensins. The CNSS was first described more than 60 years ago, but its embryological origin is totally unknown and its role is still poorly understood. Paradoxically, it is almost no longer studied today. Recent developments in imaging and genome editing could make it possible to resume investigations on CNSS in order to solve the mysteries that still surround it.
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