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Updated: Aug 11, 2025

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight MALDI-TOF Mass Spectrometry
Published on: June 10, 2018
Applications of MALDI-TOF-MS in structural characterization of synthetic polymers
A 'Bin Sun1, Siting Li1, Xinhui Kou1,2
1Shandong Provincial Education Department, Key Laboratory of Biobased Polymer Materials, College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
Abstract:
In recent years, matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been utilized to rapidly and precisely characterize the detailed molecular structures of synthetic polymers. This review summarizes recent progress regarding MALDI-TOF-MS for the characterization of synthetic polymers with a focus on specific important experimental aspects including sample preparation, the choice of matrix, the effects of cationizing agents and solvents, data processing and various applications. Finally, the recent trend of MALDI-TOF-MS development is discussed. We hope this review will be instructive for graduate students and junior users who need to use MALDI-TOF-MS as a necessary characterization technique for new synthetic polymers.
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