Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Classification of Epithelial Tissues: Stratified Epithelium

Classification of Epithelial Tissues: Stratified Epithelium

Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

Cells of the Epidermis

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...

Classification of Epithelial Tissues: Overview

Classification of Epithelial Tissues: Overview

Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Expression of protein kinase A catalytic subunits in healthy and diseased mouse kidneys.

Pflugers Archiv : European journal of physiology·2026

Same author

An Analysis of Thyrotropin Levels in Patients With Nonscarring Alopecia: A Single-Center Retrospective Comparative Study.

The Journal of clinical and aesthetic dermatology·2026

Same author

Risk of Lab Abnormalities in Nonscarring Alopecia on Low Dose Oral Minoxidil: A Retrospective Cohort Study.

Journal of cutaneous medicine and surgery·2026

Same author

Combined skeletal dysplasia and vasculopathy phenotypes associated with in-frame intragenic deletion in PRKACA.

HGG advances·2026

Same author

Zasocitinib (TAK-279), a Highly Selective Oral TYK2 Inhibitor, Demonstrates Skin Clearance in Patients with Moderate-to-Severe Plaque Psoriasis: Post Hoc Analyses of a Randomized Phase IIb Trial.

Dermatology and therapy·2026

Same author

Development of High-Affinity Ligands for Human UBR2.

Journal of medicinal chemistry·2026

Same journal

A Novel Retinoid and Salicylic Acid Topical Treatment for Moderate-Severe Acne.

Journal of drugs in dermatology : JDD·2026

Same journal

INDIVIDUAL ARTICLE: Efficacy of a Dual-Serum Cosmetic System in Women With Female Pattern Hair Loss.

Journal of drugs in dermatology : JDD·2026

Same journal

A Randomized Controlled Trial Analyzing the Likeability, Usability, and In-Use Efficacy of Mineral Sunscreens Across Diverse Skin Tones.

Journal of drugs in dermatology : JDD·2026

Same journal

Safety and Effectiveness of Two Reconstitution Volumes of Poly-L-Lactic Acid for Correction of Décolletage Wrinkles.

Journal of drugs in dermatology : JDD·2026

Same journal

Randomized Controlled Study of Bacteriophages in Acne Reveals Efficacy and Novel Mechanism for Promoting Long-Term Skin Health.

Journal of drugs in dermatology : JDD·2026

Same journal

Efficacy and Safety of Clascoterone Cream 1% and Adapalene Gel 0.3% in Patients With Acne.

Journal of drugs in dermatology : JDD·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 11, 2025

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Pigmented Basal Cell Carcinoma: An Argument for Sub-Classification.

Autumn Saizan, Susan Taylor, Nada Elbuluk

Journal of Drugs in Dermatology : JDD

|February 6, 2023

Summary

This summary is machine-generated.

Pigmented basal cell carcinoma (BCC) warrants further subclassification into superficial, nodular, or morpheaform types. This could improve treatment and outcomes, especially for skin of color patients facing health disparities.

More Related Videos

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells

Published on: March 3, 2016

Related Experiment Videos

Last Updated: Aug 11, 2025

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells

Published on: March 3, 2016

Area of Science:

Dermatology
Oncology
Pathology

Background:

Basal cell carcinoma (BCC) is a common skin cancer with existing subclassifications.
Pigmented basal cell carcinoma (BCC) is a recognized subtype.
Clinical observations suggest heterogeneity within pigmented BCCs.

Discussion:

This letter proposes subclassification of pigmented BCC into superficial, nodular, or morpheaform subtypes.
This approach acknowledges overlapping features with traditional BCC classifications.
The authors advocate for refining diagnostic categories based on clinical experience.

Key Insights:

Pigmented BCC may possess distinct subtypes.
Subclassification could reveal significant therapeutic differences.
Prognostic variations among pigmented BCC subtypes are anticipated.

Outlook:

Further research into pigmented BCC subtypes is crucial.
Refined classification may enhance patient management and reduce morbidity.
Addressing health disparities in skin cancer care for skin of color populations is essential.