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Updated: Aug 11, 2025

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Rapid Cellular-Resolution Skin Imaging with Optical Coherence Tomography Using All-Glass Multifocal Metasurfaces.

Jingjing Zhao1, Aidan Van Vleck1, Yonatan Winetraub1,2,3,4

  • 1Department of Structural Biology, Stanford University School of Medicine, Stanford, California94305, United States.

ACS Nano
|February 6, 2023
PubMed
Summary
This summary is machine-generated.

Metasurface technology enhances optical coherence tomography (OCT) by creating multiple focal points, significantly increasing volumetric imaging speed for noninvasive virtual biopsies. This innovation accelerates dermatological imaging and diagnosis.

Keywords:
all-glass metasurfacecellular resolutionmultifocal beamnoninvasive imagingoptical coherence tomographyphase change materialsvirtual biopsy

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Area of Science:

  • Biomedical Optics
  • Optical Engineering
  • Materials Science

Background:

  • Cellular-resolution optical coherence tomography (OCT) provides noninvasive histology-like imaging.
  • High numerical aperture (N.A.) lenses in OCT limit imaging speed due to narrow depth of field, requiring dynamic focusing.

Purpose of the Study:

  • To develop a metasurface platform for generating multiple axial foci to overcome OCT's depth-of-field limitation.
  • To enhance volumetric OCT imaging speed for applications like rapid virtual biopsy.

Main Methods:

  • Fabrication of all-glass metasurface optical elements from fused-silica wafers.
  • Integration of the metasurface into a scanning OCT system to create multifocal beams.
  • Evaluation of lateral resolution and volumetric acquisition speed in dermatological imaging.

Main Results:

  • The metasurface platform enables flexible control over the number, position, and intensity of axial foci.
  • A constant lateral resolution of 1.1 μm was maintained across all depths.
  • Volumetric OCT imaging speed was tripled for dermatological imaging, with potential for 7-fold improvement.
  • Distinct visualization of skin layers and diagnostic features for basal cell carcinoma was achieved.

Conclusions:

  • Metasurface-based multifocal OCT significantly accelerates volumetric imaging for noninvasive virtual biopsies.
  • This technology offers high resolution and compact imaging system potential.
  • The approach provides valuable morphological information for dermatological diagnostics.