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A review on the role of ADAMTS9-AS2 in different disorders
Soudeh Ghafouri-Fard1, Arian Askari2, Bashdar Mahmud Hussen3
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Recent decade has seen a tremendous progress in identification of the role of different long non-coding RNAs (lncRNAs) in human pathologies. ADAMTS9-AS2 is an example of lncRNAs with different roles in human disorders. It is mostly acknowledged as a tumor suppressor lncRNA in different types of cancers. However, it has been reported to be up-regulated in tongue squamous cell carcinoma, salivary adenoid cystic carcinoma and glioblastoma. Moreover, ADAMTS9-AS2 is possibly involved in the pathoetiology of pulpitis, acute ischemic stroke, type 2 diabetes and its complications. This lncRNA sponges miR-196b-5p, miR-223-3p, miR-130a-5p, miR-600, miR-223-3p, miR-27a-3p, miR-32, miR-143-3p, miR-143-3p and miR-182-5p in order to regulate downstream mRNAs. This review aims at summarization of the role of ADAMTS9-AS2 in different disorders with a particular focus on its diagnostic and prognostic values.
Insights
The long non-coding RNA ADAMTS9-AS2 has diverse roles in human diseases, acting as a tumor suppressor in some cancers but being upregulated in others. Its diagnostic and prognostic potential across various pathologies is under investigation.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Long non-coding RNAs (lncRNAs) play crucial roles in human diseases.
- ADAMTS9-AS2 is an example of a lncRNA with multifaceted roles in human pathologies.
- While often considered a tumor suppressor, ADAMTS9-AS2 is upregulated in specific cancers like glioblastoma.
Purpose of the Study:
- To review the diverse roles of ADAMTS9-AS2 in human disorders.
- To focus on the diagnostic and prognostic significance of ADAMTS9-AS2.
- To elucidate the molecular mechanisms involving ADAMTS9-AS2, including its sponging activity.
Main Methods:
- Literature review of studies on ADAMTS9-AS2.
- Analysis of ADAMTS9-AS2 expression in various diseases.
- Investigation of ADAMTS9-AS2's molecular interactions (e.g., miRNA sponging).
Main Results:
- ADAMTS9-AS2 exhibits context-dependent roles, acting as a tumor suppressor in some cancers and being upregulated in others (e.g., tongue squamous cell carcinoma, salivary adenoid cystic carcinoma, glioblastoma).
- ADAMTS9-AS2 is implicated in the pathoetiology of conditions such as pulpitis, acute ischemic stroke, and type 2 diabetes.
- This lncRNA regulates downstream mRNAs by sponging various microRNAs, including miR-196b-5p, miR-223-3p, and miR-143-3p.
Conclusions:
- ADAMTS9-AS2 presents a complex role in human diseases, extending beyond its known tumor suppressor function.
- Further research into ADAMTS9-AS2's regulatory network and interactions is warranted.
- ADAMTS9-AS2 holds potential as a diagnostic and prognostic biomarker for various human disorders.
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