Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in

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Nigel J Hall1,2, Frances C Sherratt3, Simon Eaton4

  • 1University Surgery Unit, Faculty of Medicine, University of Southampton, Southampton, UK n.j.hall@soton.ac.uk.

BMJ Paediatrics Open
|February 6, 2023
PubMed

Insights

Non-operative treatment for acute appendicitis in children shows better short-term quality of life and faster recovery than surgery. This feasibility trial suggests important differences in patient-centered outcomes for future research.

Area of Science:

  • Pediatric Surgery
  • Clinical Trials

Background:

  • Non-operative management is an alternative to appendectomy for uncomplicated acute appendicitis in children.
  • Patient-centered outcomes comparing these treatments are not well-documented.

Purpose of the Study:

  • To investigate and compare patient-centered outcomes between non-operative treatment and appendectomy for acute appendicitis in children.
  • To assess the feasibility of a randomized trial comparing these treatment modalities.

Main Methods:

  • A feasibility randomized trial was conducted.
  • Participants were randomized to either non-operative treatment or appendectomy.
  • Patient-centered outcomes were collected and analyzed.

Main Results:

  • Children receiving non-operative treatment reported higher short-term quality of life scores.
  • Non-operative treatment led to a shorter duration of analgesia requirement.
  • Faster return to normal activities and shorter parental absence from work were observed with non-operative treatment.

Conclusions:

  • Preliminary data suggest significant differences in recovery profiles and quality of life between non-operative treatment and appendectomy.
  • These findings highlight the importance of patient-centered outcomes in treatment decisions for acute appendicitis.
  • A larger randomized controlled trial is warranted to confirm these preliminary findings.

Keywords:
Gastroenterology

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