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Related Experiment Video

Updated: Aug 11, 2025

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
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Increased dendritic cell density and altered morphology in allergic conjunctivitis.

Zahra Tajbakhsh1, Blanka Golebiowski2, Fiona Stapleton2

  • 1School of Optometry and Vision Science, UNSW, Sydney, NSW, Australia. z.tajbakhsh@unsw.edu.au.

Eye (London, England)
|February 7, 2023
PubMed
Summary

Dendritic cells (DC) in the cornea and conjunctiva are increased in allergic conjunctivitis, indicating an upregulated ocular immune response. This suggests a heightened capacity for antigen capture by these cells in allergic eye disease.

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Area of Science:

  • Ophthalmology
  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are known to play a role in vernal keratoconjunctivitis.
  • Their function in more common forms of allergic eye disease is less understood.

Purpose of the Study:

  • To evaluate corneal and conjunctival epithelial DC density, morphology, and distribution in allergic conjunctivitis.
  • To compare these parameters between individuals with allergic conjunctivitis and healthy controls.

Main Methods:

  • A prospective, observational study involving 66 participants (33 with allergic conjunctivitis, 33 controls).
  • In vivo confocal microscopy (IVCM) was used to assess DC at multiple ocular surface locations.
  • DC density and morphology (cell body size, presence/type of dendrites) were quantified.

Main Results:

  • Higher DC density was observed in allergic participants across most ocular locations compared to controls (p ≤ 0.01).
  • Specifically, increased density was noted at the corneal centre, periphery, limbus, and conjunctiva.
  • Allergic participants exhibited larger DC bodies and a greater proportion of DCs with dendrites at the corneal centre (p ≤ 0.02).

Conclusions:

  • Corneal and conjunctival DC density and morphology are altered in allergic conjunctivitis.
  • These findings suggest an upregulated ocular surface immune response.
  • The results support an increased antigen-capture capacity of DCs in allergic conjunctivitis.