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Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond

Zhiyuan Wu1,2, Jinqi Wang1, Haiping Zhang1

  • 1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen Street, Beijing, 100069, China.

BMC Medicine
|February 7, 2023
PubMed

Insights

Remnant cholesterol (RC) is linked to joint arteriosclerosis and atherosclerosis progression, independent of LDL-C. High RC levels indicate increased risk, suggesting RC may be an earlier predictor of cardiovascular disease than LDL-C.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Epidemiology

Background:

  • Arteriosclerosis and atherosclerosis are key contributors to cardiovascular disease (CVD) risk.
  • Remnant cholesterol (RC) is a known CVD predictor, but its role in combined arteriosclerosis and atherosclerosis progression is unclear.

Purpose of the Study:

  • To evaluate the association between remnant cholesterol (RC) and joint arteriosclerosis and atherosclerosis progression trajectories in the general population.

Main Methods:

  • Utilized data from five biennial surveys (2010-2019) of the Beijing Health Management Cohort.
  • Employed a multi-trajectory model to identify progression patterns of arteriosclerosis and atherosclerosis using brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI).
  • Conducted discordance analyses comparing RC and low-density lipoprotein cholesterol (LDL-C) using ordinal logistic models.

Main Results:

  • Identified three distinct arteriosclerosis and atherosclerosis progression patterns among 3186 participants.
  • Found RC significantly associated with baPWV and ABI progression (OR: 1.20; 95% CI: 1.13-1.28 per 10 mg/dL).
  • High RC levels increased risk of joint arteriosclerosis and atherosclerosis progression, even with optimal LDL-C.

Conclusions:

  • Remnant cholesterol (RC) is independently associated with joint arteriosclerosis and atherosclerosis progression, beyond LDL-C levels.
  • RC may serve as an earlier risk factor for arteriosclerosis and atherosclerosis compared to LDL-C in the general population.
Abstract

Keywords:
Ankle brachial indexArteriosclerosis and atherosclerosisBrachial-ankle pulse wave velocityLDL cholesterolRemnant cholesterol

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