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Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Related Experiment Video

Updated: Aug 11, 2025

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

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Pain versus anxiety during electrodiagnostic studies

Lawrence R Robinson¹

¹Physicial Medicine and Rehabilitation, University of Toronto, Toronto, Ontario, Canada.

|February 7, 2023

Summary

No abstract available in PubMed .

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