Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

651
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
651
Neural Regulation01:37

Neural Regulation

39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

1.0K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.0K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

3.0K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
3.0K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

751
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
751
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistant Hypertension Variants Link to Hyperaldosteronism and Potassium Levels.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Genome-wide association study in 21,271 individuals identifies 9 novel loci associated with circulating CD34<sup>+</sup> hematopoietic stem and progenitor cell levels.

HemaSphere·2026
Same author

Association of HDL cholesterol, apolipoprotein AI, and E concentrations with foetal growth and placental insufficiency.

Cardiovascular research·2026
Same author

Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation.

Bone marrow transplantation·2026
Same author

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.

Nature communications·2026
Same author

Low-Density Lipoprotein Cholesterol Lowering With Inclisiran Plus Usual Care in Recent Acute Coronary Syndrome: VICTORION-INCEPTION, a Randomized, Controlled, Open-Label Trial.

Journal of the American Heart Association·2026

Related Experiment Video

Updated: Aug 11, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.1K

Genetic variants associated with syncope implicate neural and autonomic processes.

Hildur M Aegisdottir1,2, Rosa B Thorolfsdottir1, Gardar Sveinbjornsson1

  • 1deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 101, Iceland.

European Heart Journal
|February 7, 2023
PubMed
Summary
This summary is machine-generated.

This study identified 18 genetic variants linked to syncope, revealing its distinct genetic architecture. Findings highlight neural regulation and cardiovascular links, emphasizing thorough patient assessment.

Keywords:
PTPRN2GWASImprintingMeta-analysisSyncopeVasovagal reaction

More Related Videos

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.7K
Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

3.1K

Related Experiment Videos

Last Updated: Aug 11, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.1K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.7K
Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
09:20

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

Published on: July 5, 2021

3.1K

Area of Science:

  • Genetics
  • Cardiology
  • Neurology

Background:

  • Syncope is a common yet challenging condition with unclear pathophysiology and prognostic implications.
  • Understanding the genetic basis of syncope is crucial for improved diagnosis and management.

Approach:

  • A large-scale genome-wide association meta-analysis involving over 56,000 syncope cases and 890,000 controls was conducted.
  • Follow-up assessments were performed on additional cohorts, and genetic variants were analyzed for their association with syncope and related traits.

Key Points:

  • Identified 18 independent syncope-associated genetic variants, 17 of which are novel.
  • Syncope variants were preferentially located in neural-specific regulatory regions, implicating neural processes.
  • Mendelian randomization suggested a causal effect of coronary artery disease on syncope.
  • A polygenic score for syncope showed genetic correlation with cardiovascular disorders, diabetes, depression, and reduced lifespan.

Conclusions:

  • Syncope possesses a distinct genetic architecture involving neural regulation and cardiovascular factors.
  • The findings underscore the importance of comprehensive cardiovascular assessment in individuals presenting with syncope.