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Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
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Arrhythmia-associated Calmodulin Variants Interact with KCNQ1 to Confer Aberrant Membrane Trafficking and Function

Po Wei Kang, Lucy Woodbury, Paweorn Angsutararux

    Biorxiv : the Preprint Server for Biology
    |February 7, 2023
    PubMed
    Summary

    Missense variants in calmodulin (CaM) can cause arrhythmias. This study shows CaM variants affect KCNQ1 channel function and trafficking, contributing to heart rhythm disorders.

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