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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
Published on: December 12, 2019
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Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion
Matthew J White1, Kyle A Jacobs1,2, Tania Singh1,3
1Department of Cell and Tissue Biology, University of California San Francisco, San Francisco CA, 94143, USA.
Biorxiv : the Preprint Server for Biology
|February 7, 2023
Summary
Loss of Notch1 disrupts duct development by affecting cell structure, not gene activity. A non-transcriptional Notch1 mechanism stabilizes cell junctions and actin, crucial for tissue morphogenesis.
Area of Science:
- Cell Biology
- Developmental Biology
- Tissue Engineering
Background:
- Notch receptors are key regulators of tissue development, influencing cell architecture and gene expression.
- The precise mechanisms by which Notch receptors generate diverse biological outputs remain incompletely understood.
Conclusions:
- Notch1 regulates duct morphogenesis through a transcription-independent cortical signaling pathway.
- This pathway stabilizes adherens junctions and cortical actin, influencing cell architecture.
- Notch1 integrates transcriptional and cell adhesion programs, offering new insights into its regulatory roles.
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