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Updated: Aug 11, 2025
07:21
Author Spotlight: Unraveling the Interplay Between Trichoderma stromaticum and the Mammalian Immune System
Published on: October 20, 2023
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Trichoderma after crossing kingdoms: infections in human populations
Uener Ribeiro Dos Santos1, Jane Lima Dos Santos1
1Immunobiology Laboratory, Department of Biological Science, State University of Santa Cruz, Ilhéus, BA, Brazil.
Summary
Human infections from Trichoderma, a common biofertilizer, are rising. This review details global infections, clinical features, and effective antifungal treatments for Trichoderma, aiding patient care.
Area of Science:
- Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Trichoderma, a widely used biofertilizer and biocontrol agent, is increasingly implicated in human infections.
- Growing reports highlight the challenge of treating Trichoderma infections due to high antifungal drug resistance.
Approach:
- This review synthesizes global data on Trichoderma infection sources and distribution.
- It examines clinical manifestations, therapeutic strategies, and treatment outcomes.
- Antifungal susceptibility profiles of recent Trichoderma isolates are analyzed.
Key Points:
- Infections affect both immunocompetent and immunocompromised individuals.
- Sources of infection include air, agriculture, and healthcare settings.
- Treatment is complicated by isolates with high minimum inhibitory concentrations to standard antifungals.
Conclusions:
- Effective therapeutic strategies and optimal antifungal treatments are highlighted.
- Further evaluation of specific antifungal drugs is recommended for emerging Trichoderma infections.
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