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Updated: Aug 11, 2025

Correlative Light Electron Microscopy CLEM for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells
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Identifying Active Progeny Virus Particles in Formalin-Fixed, Paraffin-Embedded Sections Using Correlative Light and

Toshiya Itoh1, Satoshi Yamada2, Isao Ohta3

  • 1Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan; Institute for NanoSuit Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Laboratory Investigation; a Journal of Technical Methods and Pathology
|February 7, 2023
PubMed
Summary

This study introduces a new method to visualize virus particles in FFPE tissue using field emission scanning electron microscopy. This technique enhances 3D imaging of viral particles, aiding in understanding virus-related diseases.

Keywords:
FFPENanoSuitSEMvirus particles

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