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Updated: Aug 11, 2025

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Helicobacter pylori treatment knowledge, access and barriers: A cross-sectional study
Kimberly S Bailey1, Heidi E Brown1, Viktor Lekic2
1Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, USA.
Helicobacter pylori (Hp) knowledge is low in the US, with many patients not completing treatment. Increasing awareness and addressing treatment barriers could reduce gastric cancer risks.
Area of Science:
- Medical Microbiology
- Gastroenterology
- Public Health
Background:
- Helicobacter pylori (Hp) is a prevalent bacterial infection globally and a significant risk factor for gastric cancer (GC).
- Disparities in Hp infection rates and related diseases exist within the United States.
- Understanding Hp infection is crucial as it is treatable and knowledge influences health-seeking behaviors.
Purpose of the Study:
- To assess the baseline knowledge of Helicobacter pylori (Hp) among US adults.
- To identify barriers to seeking and adhering to Hp care.
Main Methods:
- A cross-sectional study was conducted with 1042 participants recruited via the Amazon MTurk online platform.
- Data collected included self-reported knowledge of Hp, personal or family history of Hp diagnosis, and experiences with treatment.
Main Results:
- Over half of respondents (52.3%) had prior Hp knowledge; 11.7% reported personal treatment, and 21.4% reported family diagnoses.
- Among those treated, 78% experienced gastrointestinal upset, and 21% did not complete prescribed medications.
- Beliefs about treatment severity (70%) and knowledge of Hp causing GC (81%) significantly influenced willingness to seek or continue care.
Conclusions:
- Low awareness of Helicobacter pylori (Hp) and high rates of self-reported treatment non-compliance were observed in this US online sample.
- Enhancing public awareness of Hp and overcoming treatment adherence challenges can potentially decrease antibiotic resistance and prevent GC progression.
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