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Updated: Aug 11, 2025
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A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
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Right Ventricular Architectural Remodeling and Functional Adaptation in Pulmonary Hypertension
Emilio A Mendiola1, Denielli da Silva Gonçalves Bos2,3,4,5, Dana M Leichter5
1Department of Biomedical Engineering, Texas A&M University, College Station (E.A.M., R.A.).
Circulation. Heart Failure
|February 7, 2023
Summary
Adaptive right ventricle (RV) remodeling in pulmonary hypertension (PH) may improve RV function. Assessing RV architecture is crucial for understanding its prognostic and therapeutic significance in PH patients.
Area of Science:
- Cardiovascular Research
- Medical Imaging
- Pulmonary Hypertension
Background:
- Global right ventricle (RV) function indices offer limited insight into pulmonary hypertension (PH) mechanisms.
- RV myocardial architectural remodeling in PH is observed, but its adaptive role remains unclear.
Purpose of the Study:
- To investigate the relationship between RV myoarchitecture and RV adaptation in rodent models of PH.
- To explore the impact of RV architectural remodeling on RV function and pulmonary arterial coupling.
Main Methods:
- Utilized generalized Q-space imaging and tractography to quantify RV free wall myoarchitecture in two PH rodent models.
- Developed computational models to predict RV wall strains and analyzed correlations between hemodynamics, RV strains, and structural measures.
Main Results:
- Mildly maladapted PH rats showed decreased helical range of RV free wall fiber orientation compared to severely maladapted rats.
- Preserved global circumferential strain and better RV-pulmonary arterial coupling were observed in mildly maladapted PH rats.
- Helical range positively correlated with RV-pulmonary arterial coupling and stroke volume index.
Conclusions:
- Adaptive RV architectural remodeling may enhance RV function in the context of PH.
- Routine assessment of RV architecture in PH patients could offer prognostic and therapeutic insights.
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