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Related Experiment Video

Updated: Aug 11, 2025

Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
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Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes.

Alexis M Ziemba1,2,3, Mary Clare Crochiere Woodson1,2, Jessica L Funnell1,2

  • 1Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

ACS Applied Bio Materials
|February 7, 2023
PubMed
Summary

This study developed a new coating for brain implants using curcumin and PEG. The coating is soft, releases curcumin over time, and shows biocompatibility in animal models, offering potential for improved brain-computer interfaces.

Keywords:
coatingcurcumindrug deliveryelectrodepolyethylene glycolpolyprodrug

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Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Medical Devices

Background:

  • Intracortical microelectrodes are crucial for brain-computer interfaces (BCIs) but suffer from reduced recording ability over time.
  • Neuroinflammation and scarring around the electrodes contribute to signal degradation.
  • Curcumin, known for its anti-inflammatory properties, offers potential therapeutic benefits.

Purpose of the Study:

  • To develop and evaluate a novel, soft, and hydrophilic coating for intracortical microelectrodes using a curcumin-polyethylene glycol (PEG) copolymer.
  • To assess the biocompatibility and long-term stability of the poly(curcumin-PEG1000 carbamate) (PCPC) coating in vitro and in vivo.
  • To investigate the potential of PCPC as a material for improving the longevity and performance of neural implants.

Main Methods:

  • Fabrication of a 300 nm-thick PCPC coating on silicon wafers.
  • Characterization of the coating's physical properties (hardness, hydrophilicity).
  • In vitro assessment of curcumin release kinetics and coating stability.
  • In vivo evaluation of tissue response (inflammation, scarring, neuron viability, myelin damage) in a rat model using coated and uncoated microelectrodes.

Main Results:

  • The PCPC coating was soft and hydrophilic, significantly reducing silicon wafer hardness.
  • Curcumin eluted from the coating over one week, with the coating remaining largely intact after 8 weeks.
  • In vivo implantation showed no significant differences in tissue inflammation, scarring, neuron viability, or myelin damage between PCPC-coated and uncoated probes.

Conclusions:

  • The study successfully demonstrated the biocompatibility of a novel polymerized curcumin coating (PCPC) for intracortical microelectrodes.
  • PCPC exhibits desirable properties like softness, hydrophilicity, and sustained curcumin release.
  • This work provides a foundation for designing advanced poly(pro-curcumin) polymers for enhanced neural implant performance.