C-N Coupling through Hydroaminoalkylation on a Single-Atom Rh Heterogeneous Catalyst
Yuting Li1, Yu Tang1, Franklin Feng Tao1
1Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS 66049, USA.
A new Rhodium single-atom catalyst (Rh1/P25) efficiently synthesizes tertiary amines via hydroaminoalkylation. This stable, reusable heterogeneous catalyst offers high selectivity and activity for fine chemical production.
Area of Science:
- Catalysis
- Materials Science
- Organic Synthesis
Background:
- C-N coupling is crucial for synthesizing fine chemicals.
- Hydroaminoalkylation of olefins is a tandem reaction involving hydroformylation and reductive amination.
Purpose of the Study:
- To develop a stable, supported single-atom catalyst for hydroaminoalkylation.
- To evaluate the catalyst's activity and selectivity in C-N coupling reactions.
Main Methods:
- Synthesized singly dispersed Rhodium atoms (Rh1) anchored on TiO2 (P25) nanoparticles.
- Tested the Rh1/P25 catalyst in six different hydroaminoalkylation reactions of olefins and amines.
Main Results:
- The Rh1/P25 catalyst demonstrated high activity and selectivity (>90%) for producing tertiary amines.
- The catalyst's performance was comparable or superior to reported molecular catalysts.
- The heterogeneous catalyst was easily separated, reused, and recycled with low cost.
Conclusions:
- Singly dispersed Rh1 atoms on P25 represent an effective heterogeneous catalyst for hydroaminoalkylation.
- This single-atom heterogeneous catalysis offers advantages in separation, reusability, and cost-effectiveness over molecular catalysts.
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