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Serum platelet distribution width predicts cardiovascular and all-cause mortality in patients undergoing peritoneal

Heng-Mei Zhu1,2, Yi-Yi Xiong3, Yan-Bing Chen1

  • 1Department of Nephrology, First Affiliated Hospital of Nanchang University, Nanchang, China.

Postgraduate Medicine
|February 7, 2023
PubMed

Insights

High platelet distribution width (PDW) levels predict increased cardiovascular and all-cause mortality in peritoneal dialysis (PD) patients. This association is stronger for all-cause mortality in female PD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Hematology

Background:

  • Platelet distribution width (PDW) is a known predictor of mortality in cardiovascular disease (CVD).
  • The prognostic value of PDW in patients undergoing peritoneal dialysis (PD) remains under-explored.

Purpose of the Study:

  • To investigate the association between PDW levels and cardiovascular mortality.
  • To evaluate PDW as a predictor of all-cause mortality in PD patients.
  • To explore potential sex-based differences in these associations.

Main Methods:

  • Retrospective cohort study of 762 PD patients from 2005-2017.
  • Follow-up until 2021 to assess cardiovascular and all-cause mortality.
  • Survival analysis using Kaplan-Meier and Cox regression, including multivariate adjustment.

Main Results:

  • High PDW levels were independently associated with increased CVD mortality (HR: 1.583) and all-cause mortality (HR: 1.313) in PD patients.
  • A significant interaction by sex was observed for all-cause mortality.
  • Female PD patients with high PDW showed a markedly higher risk of all-cause mortality (HR: 1.986).

Conclusions:

  • Elevated PDW is an independent risk factor for both cardiovascular and all-cause mortality in the PD population.
  • Sex-specific differences in PDW's association with mortality warrant further investigation.
  • PDW may serve as a valuable prognostic biomarker in PD patients.
Abstract

Keywords:
Platelet distribution widthcardiovascular diseasemortalityperitoneal dialysissex differences

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