Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effects of Creep01:25

Effects of Creep

209
Creep in concrete, the gradual deformation under prolonged stress, significantly impacts the integrity of structures. For reinforced concrete beams, it can be a vital design consideration, as it increases deflection, sometimes necessitating additional design measures. In columns, especially slender ones under eccentric loads, creep can cause buckling, compromising their stability. However, creep can be beneficial in indeterminate structures by mitigating stresses that arise from shrinkage,...
209
Cell Migration01:09

Cell Migration

17.1K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.1K
Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

2.3K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
2.3K
Resting Potential Decay01:15

Resting Potential Decay

5.0K
The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
5.0K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.0K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.0K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of major Ptchd1 isoforms causes autistic traits in social behavior and communication.

Molecular psychiatry·2026
Same author

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism.

Nature·2026
Same author

Temporally gated offline engram ensemble reverberation in the lateral amygdala is required for fear memory consolidation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Microglia-dependent regulation of fear memory extinction.

Nature neuroscience·2026
Same author

Engrams and Memory: My Scientific "Eras Tour".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Neuronal competition shapes the encoding, consolidation, and retrieval of precise spatial memories in mice.

Current biology : CB·2026
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Related Experiment Video

Updated: Aug 11, 2025

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus
09:59

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus

Published on: October 11, 2017

12.8K

Exercise accelerates place cell representational drift.

Mitchell L de Snoo1, Adam M P Miller2, Adam I Ramsaran3

  • 1Program in Neurosciences and Mental Health, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4; Institute of Medical Sciences, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 2374, Toronto, Ontario, Canada, M5S 1A8.

Current Biology : CB
|February 7, 2023
PubMed
Summary
This summary is machine-generated.

Neural circuit remodeling, driven by voluntary exercise, accelerates representational drift in the hippocampus. This suggests structural brain changes underlie shifts in neural activity patterns over time.

More Related Videos

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.4K
The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
08:42

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

1.2K

Related Experiment Videos

Last Updated: Aug 11, 2025

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus
09:59

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus

Published on: October 11, 2017

12.8K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.4K
The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
08:42

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

1.2K

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Systems Neuroscience

Background:

  • Stable neural ensembles are traditionally linked to consistent learned behaviors and memory.
  • Longitudinal studies reveal representational drift, where neuronal activity patterns change over time despite stable behaviors.
  • The role of neural circuit remodeling in driving this representational drift remains unclear.

Purpose of the Study:

  • To investigate whether changes in structural connectivity (neural circuit remodeling) contribute to representational drift.
  • To examine the impact of voluntary exercise, a known promoter of hippocampal remodeling, on representational drift.

Main Methods:

  • Tracking spatial representations of a familiar environment in hippocampal CA1 place cells over two weeks.
  • Comparing mice housed with a running wheel (promoting neurogenesis and remodeling) to conventionally housed control mice.
  • Analyzing changes in neuronal activity patterns in relation to exercise-induced hippocampal circuit remodeling.

Main Results:

  • Mice housed with a running wheel showed accelerated representational drift in their hippocampal CA1 place cell activity compared to control mice.
  • Voluntary exercise promotes hippocampal circuit remodeling through adult neurogenesis and altered synaptic connections.
  • The findings indicate a correlation between enhanced circuit remodeling and faster representational drift.

Conclusions:

  • Hippocampal circuit remodeling, influenced by voluntary exercise, appears to drive representational drift.
  • Structural changes in neural circuits may underlie the dynamic nature of neural representations over time.
  • This study provides evidence linking experience-dependent brain plasticity to the stability of neural representations.