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Related Experiment Video

Updated: Aug 11, 2025

Place and Response Learning in the Open-field Tower Maze

Place and Response Learning in the Open-field Tower Maze

Published on: October 28, 2015

Limbic progesterone receptors regulate spatial memory.

Suchitra Joshi¹, Cedric L Williams², Jaideep Kapur^3,4,5

¹Department of Neurology, University of Virginia, Health Sciences Center, P.O. Box 801330, Charlottesville, VA, 22908, USA. sj9z@virginia.edu.

Scientific Reports

|February 7, 2023

Summary

This summary is machine-generated.

Progesterone receptors (PRs) are crucial for spatial memory in male mice. Deleting PRs impairs the ability to learn and recall spatial information, but not fear conditioning.

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Area of Science:

Neuroscience
Reproductive Biology
Cognitive Science

Background:

Progesterone receptors (PRs) are involved in reproduction.
The role of PRs in spatial declarative memory remains unclear.
PRs are expressed in brain regions vital for spatial memory, like the hippocampus and entorhinal cortex (EC).

Purpose of the Study:

To investigate the function of PRs in spatial and non-spatial cognitive learning in male mice.
To determine if PR deletion affects memory performance in specific cognitive tasks.

Main Methods:

Utilized progesterone receptor knockout (PRKO) male mice.
Assessed cognitive performance using novel object recognition, object placement, Y-maze alternation, and Morris-Water Maze (MWM) tasks.
Examined the impact of EC-specific PR deletion.

Main Results:

PRKO mice showed deficits in recognizing novel objects and object locations.
Spatial memory was impaired in PRKO mice across Y-maze and MWM tasks.
Fear conditioning performance was unaffected by PR removal.

Conclusions:

PRs play a significant role in facilitating spatial, declarative memory in male mice.
PRs are essential for cognitive functions related to spatial navigation and memory.
These findings may offer insights into reproductive partner-finding behaviors.