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Updated: Aug 11, 2025

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Longitudinal association between adiposity changes and lung function deterioration.

Youngmok Park1, Jiyoung Kim2,3, Young Sam Kim1

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

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|February 8, 2023
PubMed
Summary
This summary is machine-generated.

Increased adiposity, particularly central obesity, is linked to long-term declines in lung function (forced vital capacity and forced expiratory volume in 1 second) in middle-aged Asian adults.

Keywords:
Abdominal obesityAdiposityBody compositionSpirometryWaist–hip ratio

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Area of Science:

  • Pulmonary Medicine
  • Metabolic Health
  • Epidemiology

Background:

  • The relationship between body fat and lung capacity over time is not well understood.
  • Investigating long-term adiposity changes and their impact on lung function in a general Asian population is crucial.

Purpose of the Study:

  • To examine the longitudinal association between changes in adiposity and lung function.
  • To identify specific measures of adiposity that impact lung function over time.

Main Methods:

  • A community-based prospective cohort study included 5011 middle-aged Asian participants.
  • Spirometry and bio-electrical impedance analysis were conducted biannually over a median follow-up of 8 years.
  • Multivariate linear mixed regression models analyzed the association between adiposity changes (fat mass index and waist-to-hip ratio) and lung function.

Main Results:

  • Increased fat mass index (FMI) was inversely associated with forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) in both men and women.
  • Increased waist-to-hip ratio (WHR) was significantly associated with lower FVC and FEV1 in men.
  • A rising WHR correlated with a faster decline in lung function, irrespective of overall fat mass changes.

Conclusions:

  • Adiposity is a significant factor in the long-term impairment of lung function.
  • Central obesity, indicated by WHR, is a primary driver of lung function decline in this population.
  • These findings highlight the importance of managing central obesity for respiratory health in middle-aged Asian adults.