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Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

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Related Experiment Video

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A Standardized Pathology Report for Gastric Cancer: 2nd Edition.

Young Soo Park1, Myeong-Cherl Kook2, Baek-Hui Kim3

  • 1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Journal of Gastric Cancer
|February 8, 2023
PubMed
Summary

A revised standardized pathology report for gastric cancer (GC) has been developed to incorporate recent advances in diagnosis and molecular genetics. This updated report aids in GC prognosis and facilitates collaborative research.

Keywords:
Endoscopic resectionGastrectomyMolecular pathologyPathology reportStandardizationStomach neoplasms

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Area of Science:

  • Pathology
  • Oncology
  • Genetics

Background:

  • The first edition of the standardized pathology report for gastric cancer (GC) was published 17 years ago.
  • Significant advancements in GC diagnosis, molecular genetics, and management have occurred since the first edition.
  • These advancements necessitate an updated report to reflect current knowledge and practices.

Purpose of the Study:

  • To publish a second edition of the standardized pathology report for gastric cancer.
  • To incorporate recent diagnostic and prognostic factors, including molecular biomarkers.
  • To provide a comprehensive yet adaptable report for routine pathology services and specialized research.

Main Methods:

  • A committee was formed within the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists.
  • The committee revised the standardized pathology report, dividing it into standard and conditional data elements.
  • Standard elements include basic findings and prognostic indicators for routine use.
  • Conditional elements encompass advanced factors like molecular biomarkers for selective use.

Main Results:

  • The second edition of the standardized pathology report for gastric cancer is now available.
  • It features standard data elements for essential diagnostic and prognostic information.
  • It also includes conditional data elements for advanced molecular and therapeutic factors.

Conclusions:

  • The updated standardized pathology report for gastric cancer will improve diagnostic accuracy and prognostic prediction.
  • It is expected to enhance the quality of surgical pathology services for GC.
  • The report will facilitate large-scale, multidisciplinary research collaborations in gastric cancer studies.